Molecules, Cells & Therapies
SickKids is uniquely placed to identify new targets for therapeutic interventions in diseases that begin in childhood and affect adult life, developing new molecular therapies and carrying them through to clinical impact. An interdisciplinary approach unites researchers to develop an innovative pipeline approach to target discovery and drug development for childhood diseases.
Cancer & Stem Cell Biology
Despite enormous advances in the past 20 years, cancer is the most common cause of disease-related death in children. SickKids is the largest childhood cancer treatment centre in Canada and a major contributor to international paediatric clinical trials. SickKids researchers are leading studies in cancer stem cells, are poised to identify new predictors and are working to develop innovative therapies.
Genetics & Genomic Medicine
There has been an explosion of knowledge in human genetics and genetic diseases in the past decade, which will increasingly influence prevention, treatment and cures for diseases. SickKids has been a leader in this research, and will continue to focus on the identification of genes and genomic variants impacting on child health, translation of genetic findings into clinical diagnostic tests, development of novel therapies based on these finding and evaluation of the efficacy and social impact of new genetic tests and therapies.
Patients, Populations & Policy
Focusing on outcomes and impacts, SickKids researchers seek to improve the health and quality of life of children and their families. Undertaking studies on issues that matter to Canadians, SickKids scientists are developing evidence-based methods to ensure research findings lead to more effective and efficient delivery of health-care, including the management of asthma, obesity, eating disorders and Type 1 diabetes, as well as access to primary care, evaluation of the effectiveness of new health technologies, injury prevention and effective health promotion strategies for youth at risk of mental illness.
Organ Systems & Disease
Tens of thousands of Canadian children suffer from congenital birth defects and complex and chronic diseases of the cardiovascular, immune, endocrine, respiratory and musculoskeletal systems – and retain these problems as adults. Early intervention is key to preventing a lifetime of health challenges and starts with understanding how disease begins before birth and in childhood. SickKids focus on the development of new diagnostic techniques such as imaging technologies and new treatments will bring transformative new approaches to respiratory diseases, tissue reconstructive surgery, cardiac anomalies and joint disease in children.
Brain & Behaviour
Brings together a team of basic scientists and clinician-scientists and health professionals to address issues such as pain management; brain injury and repair — including traumatic brain injury; vision and auditory perception; epilepsy; cognitive and neuropsychiatric disorders such as ADHD, autism, obsessive compulsive disorder and schizophrenia.